You can pry gentoo from my cold dead hands. The ability to do things like mix LTS and git HEAD packages at will is yuuge, as well as the dynamic dependency graph based on enabled features. Some newer distros like Nix and Guix come close, and even offer the ability to skip compilation via their package caches, but they have a number of pain points in my personal experience.
Basically, on Fedora you are a guinea pig for whatever new tech Red Hat (now IBM) is considering rolling out. It is a well polished distro and I have set it up on several people’s computers, but they will be among the first to just foist a whole new replacement subsystem on their users. Can be interesting if you like experimental shit (and what comes to Fedora tends to stick around [i.e. PulseAudio, systemd], unlike a lot of the shit Canonical has tried to introduce [i.e. Upstart, Mir]). Can be a major headache if you are trying to use something which requires iptables and they have jumped into nftables with both feet (for instance).